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        Rabbit Anti-CD3D/BF594 Conjugated antibody (bs-23465R-BF594)
        訂購熱線:400-901-9800
        訂購郵箱:sales@bioss.com.cn
        訂購QQ:  400-901-9800
        技術支持:techsupport@bioss.com.cn
        說 明 書: 100ul  
        100ul/2980.00元
        大包裝/詢價
        產品編號 bs-23465R-BF594
        英文名稱 Rabbit Anti-CD3D/BF594 Conjugated antibody
        中文名稱 BF594標記的CD3D抗體
        別    名 CD3 antigen delta subunit;CD3 delta;CD3d antigen delta polypeptide;CD3d molecule delta;CD3D_HUMAN;IMD19;OKT3 delta chain ;T cell receptor T3 delta chain ;T-cell surface glycoprotein CD3 delta chain;T3D.   
        規格價格 100ul/2980元 購買        大包裝/詢價
        說 明 書 100ul  
        研究領域 腫瘤  免疫學  干細胞  t-淋巴細胞  b-淋巴細胞  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        交叉反應 (predicted: Human, )
        產品應用 ICC=1:50-200 IF=1:50-200 
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        分 子 量 19kDa
        性    狀 Lyophilized or Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthetic peptide derived from human CD3D
        亞    型 IgG
        純化方法 affinity purified by Protein A
        儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4.
        保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
        產品介紹 background:
        CD3D (CD3d Molecule) is a Protein Coding gene. Diseases associated with CD3D include Immunodeficiency 19 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include protein heterodimerization activity and transmembrane signaling receptor activity. An important paralog of this gene is CD3G.

        Function:
        The CD3 complex mediates signal transduction.

        Subunit:
        The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta

        Subcellular Location:
        Membrane.

        DISEASE:
        Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.

        Similarity:
        Contains 1 ITAM domain.

        Database links:

        Entrez Gene: 915 Human

        Entrez Gene: 12500 Mouse

        Omim: 186790 Human

        SwissProt: P04234 Human

        SwissProt: P04235 Mouse

        Unigene: 504048 Human

        Unigene: 4527 Mouse



        Important Note:
        This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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