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        Rabbit Anti-phospho-CD130/gp130 (Ser782)/PE-Cy5.5 Conjugated antibody (bs-10122R-PE-Cy5.5)
        訂購熱線:400-901-9800
        訂購郵箱:sales@bioss.com.cn
        訂購QQ:  400-901-9800
        技術支持:techsupport@bioss.com.cn
        說 明 書: 100ul  
        100ul/2980.00元
        大包裝/詢價
        產品編號 bs-10122R-PE-Cy5.5
        英文名稱 Rabbit Anti-phospho-CD130/gp130 (Ser782)/PE-Cy5.5 Conjugated antibody
        中文名稱 PE-Cy5.5標記的磷酸化gp130抗體
        別    名 gp130 (phospho S782); gp130 (phospho Ser782); p-gp130 (Ser782); Interleukin-6 receptor subunit beta; IL-6R-beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; CDw130; Oncostatin-M receptor subunit alpha; CD_antigen; CD130; GP130 RAPS; gp130 transducer chain; GP130-RAPS; IL6 ST; IL6R-beta; IL6ST.IL6R-beta; IL6RB_HUMAN; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB.  
        規格價格 100ul/2980元 購買        大包裝/詢價
        說 明 書 100ul  
        產品類型 磷酸化抗體 
        研究領域 細胞生物  信號轉導  細胞膜受體  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
        產品應用 ICC=1:50-200 IF=1:50-200 
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        性    狀 Lyophilized or Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthesised phosphopeptide derived from human gp130 around the phosphorylation site of Ser782
        亞    型 IgG
        純化方法 affinity purified by Protein A
        儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
        保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
        產品介紹 background:
        CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

        Function:
        Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.

        Subunit:
        Interacts with INPP5D/SHIP1. Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor). Homodimer. The homodimer binds two molecules of herpes virus IL6. Component of a hexamer of two molecules each of IL6, IL6R and IL6ST. Interacts with HCK.

        Subcellular Location:
        Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

        Tissue Specificity:
        Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

        Post-translational modifications:
        Phosphorylation of Ser-782 down-regulates cell surface expression.
        Heavily N-glycosylated.

        Similarity:
        Belongs to the type I cytokine receptor family. Type 2 subfamily.
        Contains 5 fibronectin type-III domains.
        Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

        Database links:

        Entrez Gene: 3572 Human

        Entrez Gene: 16195 Mouse

        Entrez Gene: 25205 Rat

        Omim: 600694 Human

        SwissProt: P40189 Human

        SwissProt: Q00560 Mouse

        SwissProt: P40190 Rat

        Unigene: 532082 Human

        Unigene: 706627 Human

        Unigene: 4364 Mouse

        Unigene: 12138 Rat



        Important Note:
        This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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