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        Rabbit Anti-DBPA/Gold Conjugated antibody (bs-12985R-Gold)
        訂購熱線:400-901-9800
        訂購郵箱:sales@bioss.com.cn
        訂購QQ:  400-901-9800
        技術支持:techsupport@bioss.com.cn
        說 明 書: 100ul(10nm  15nm  35nm
        100ul/2980.00元
        大包裝/詢價
        產品編號 bs-12985R-Gold
        英文名稱 Rabbit Anti-DBPA/Gold Conjugated antibody
        中文名稱 膠體金標記的冷休克蛋白DBPA抗體
        別    名 Cold shock domain containing protein A; Cold shock domain-containing protein A; csdA; CSDA1; DBPA; DNA binding protein A; DNA-binding protein A; Single strand DNA binding protein NF GMB; Single-strand DNA-binding protein NF-GMB; ZO 1 associated nucleic acid binding protein; ZO1 associated nucleic acid binding protein; ZONAB; YBOX3_HUMAN; Y-box-binding protein 3.  
        規格價格 100ul/2980元 購買        大包裝/詢價
        說 明 書 100ul(10nm  15nm  35nm
        研究領域 細胞生物  信號轉導  細胞周期蛋白  轉錄調節因子  表觀遺傳學  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Rabbit, Sheep, )
        產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        分 子 量 40kDa
        性    狀 Lyophilized or Liquid
        濃    度 0.4mg/ml
        免 疫 原 KLH conjugated synthetic peptide derived from human DBPA/CSDA1
        亞    型 IgG
        純化方法 affinity purified by Protein A
        儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
        保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
        產品介紹 background:
        CSDA is a 372 amino acid nuclear and cytoplasmic protein that is highly expressed in skeletal muscle and heart. Containing one CSD (cold-shock) domain, CSDA is thought to bind to GM-CSF promoter, full length mRNA and to short RNA sequences containing a specific consensus site. CSDA is suggested to have a role in translation repression and is found in a mRNP complex with MSY2. MSY2 belongs to the Y-box family of multifunctional proteins that regulate both transcription and translation. CSDA participates in promoting cell proliferation and expression of cyclin D1 and proliferating cell nuclear antigen (PCNA). CSDA is regarded to be an important component of the mechanisms that sense epithelial density and in regulating the switch between proliferation and differentiation through complex transcriptional networks.

        Function:
        Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression.

        Subcellular Location:
        Cytoplasm. Nucleus.

        Tissue Specificity:
        Highly expressed in skeletal muscle and heart.

        Similarity:
        Contains 1 CSD (cold-shock) domain.

        Database links:

        Entrez Gene: 8531 Human

        Entrez Gene: 56449 Mouse

        Entrez Gene: 83807 Rat

        Omim: 603437 Human

        SwissProt: P16989 Human

        SwissProt: Q61478 Mouse

        SwissProt: Q68G78 Mouse

        SwissProt: Q8BPG0 Mouse

        SwissProt: Q9JKB3 Mouse

        SwissProt: Q3KRC7 Rat

        SwissProt: Q62764 Rat

        Unigene: 221889 Human

        Unigene: 299604 Mouse

        Unigene: 458000 Mouse

        Unigene: 3306 Rat



        Important Note:
        This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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