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        Rabbit Anti-HAGHL/PE-Cy7 Conjugated antibody (bs-8414R-PE-Cy7)
        訂購熱線:400-901-9800
        訂購郵箱:sales@bioss.com.cn
        訂購QQ:  400-901-9800
        技術支持:techsupport@bioss.com.cn
        說 明 書: 100ul  
        100ul/2980.00元
        大包裝/詢價
        產品編號 bs-8414R-PE-Cy7
        英文名稱 Rabbit Anti-HAGHL/PE-Cy7 Conjugated antibody
        中文名稱 PE-Cy7標記的羥基酰谷胱甘肽水解酶樣蛋白抗體
        別    名 HAGHL; HAGHL_HUMAN; Hydroxyacylglutathione hydrolase-like; Hydroxyacylglutathione hydrolase-like protein.  
        規格價格 100ul/2980元 購買        大包裝/詢價
        說 明 書 100ul  
        研究領域 腫瘤  細胞生物  免疫學  神經生物學  信號轉導  Alzheimer's  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        交叉反應 Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Sheep, )
        產品應用 IF=1:50-200 
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        分 子 量 32kDa
        性    狀 Lyophilized or Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthetic peptide derived from human HAGHL
        亞    型 IgG
        純化方法 affinity purified by Protein A
        儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
        保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
        產品介紹 background:
        The hydroxyacylglutathione hydrolase-like protein (HAGHL) is a 290 amino acid protein that belongs to the glyoxalase II family. HAGHL binds two zinc ions per subunit and acts as a hydrolase on ester bonds. The gene encoding HAGHL maps to human chromosome 16, which encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, a gastrointestinal inflammatory condition that may involve the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.

        Function:
        Hydroxyacylglutathione hydrolase (HAGH) is a thiolesterase which hydrolyses S-lactoyl-glutathione to reduced glutathione and D-lactate.

        Subcellular Location:
        Cytoplasmic and Mitochondrial

        Similarity:
        Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

        Database links:

        Entrez Gene: 84264 Human

        SwissProt: Q6PII5 Human

        Unigene: 124015 Human



        Important Note:
        This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

        克羅恩病(節段性腸炎)Crohn’s disease(segmental enteritis”,曾稱:克隆病)的研究。
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