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        Rabbit Anti-phospho-ZCWCC1 (Ser739)/APC Conjugated antibody (bs-10016R-APC)
        訂購熱線:400-901-9800
        訂購郵箱:sales@bioss.com.cn
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        說 明 書: 100ul  
        100ul/2980.00元
        大包裝/詢價
        產品編號 bs-10016R-APC
        英文名稱 Rabbit Anti-phospho-ZCWCC1 (Ser739)/APC Conjugated antibody
        中文名稱 APC標記的磷酸化ZCWCC1抗體
        別    名 AC004542.C22.1.; p-MORC2(Ser739); phospho-ZCWCC1(Ser739); CW type with coiled coil domain 1; KIAA0852; ZCW3; ZCWCC1; Zinc finger; Zinc finger CW type coiled coil domain protein 1; Zinc finger CW type with coiled coil domain 1; Zing finger CW type 3 zinc finger CW-type coiled-coil domain protein 1; MORC family CW-type zine finger 2; MORC2.  
        規格價格 100ul/2980元 購買        大包裝/詢價
        說 明 書 100ul  
        產品類型 磷酸化抗體 
        研究領域 細胞生物  轉錄調節因子  鋅指蛋白  表觀遺傳學  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        交叉反應 (predicted: Human, )
        產品應用 ICC=1:50-200 IF=1:50-200 
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        分 子 量 114kDa
        性    狀 Lyophilized or Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MORC2 around the phosphorylation site of Ser739
        亞    型 IgG
        純化方法 affinity purified by Protein A
        儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
        保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
        產品介紹 background:
        The CW domain is a structural module found in many vertebrate, parasitic and plant proteins. It consists of a mononuclear four-cysteine zinc-finger domain that plays a role in DNA binding, chromatin methylation and early embryonic development. ZCWCC1 (zinc finger CW-type coiled-coil domain protein 1), also known as MORC2 (MORC family CW-type zinc finger protein 2) or ZCW3, is a 1,032 amino acid protein that contains one CW-type zinc finger domain. ZCWCC1 is located on chromosome 22 and is ubiquitously expressed with highest expression in pancreas, smooth muscle and testis. Expression of ZCWCC1 is upregulated in hypoxia, a pathological condition characterized by an inadequate supply of oxygen in the blood.

        Function:
        May act as a transcriptional repressor. Down-regulates CA9 expression.

        Subunit:
        Interacts with HDAC4.

        Subcellular Location:
        Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus.

        Tissue Specificity:
        Highly expressed in smooth muscle, pancreas and testis.

        Similarity:
        Contains 1 CW-type zinc finger.

        Database links:
        UniProtKB/Swiss-Prot: Q9Y6X9.

        Important Note:
        This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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