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        Rabbit Anti-CD147/BF555 Conjugated antibody (bs-0684R-BF555)
        訂購熱線:400-901-9800
        訂購郵箱:sales@bioss.com.cn
        訂購QQ:  400-901-9800
        技術支持:techsupport@bioss.com.cn
        說 明 書: 100ul  
        100ul/2980.00元
        大包裝/詢價
        產品編號 bs-0684R-BF555
        英文名稱 Rabbit Anti-CD147/BF555 Conjugated antibody
        中文名稱 BF555標記的細胞外基質金屬蛋白酶誘導因子抗體
        別    名 TCSF; Emmprin; 5A11 antigen; 5F7; Basigin (Ok blood group); Basigin; Blood brain barrier HT7 antigen; BSG; CD 147; CD147 antigen; Collagenase stimulatory factor; Extracellular matrix metalloproteinase inducer; Leukocyte activation antigen M6; M6; M6 leukocyte activation antigen; neurothelin; OK; OK blood group; OK blood group antigen; TCSF; Tumor cell derived collagenase stimulatory factor; BASI_HUMAN.  
        規格價格 100ul/2980元 購買        大包裝/詢價
        說 明 書 100ul  
        研究領域 腫瘤  免疫學  合成與降解  細胞表面分子  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        交叉反應 Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Rabbit, Guinea Pig, )
        產品應用 IF=1:50-200 
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        分 子 量 40kDa
        性    狀 Lyophilized or Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthetic peptide derived from human TCSF
        亞    型 IgG
        純化方法 affinity purified by Protein A
        儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
        保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
        產品介紹 background:
        The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008

        Function:
        Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

        Subunit:
        Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM. Interacts with AJAP1.

        Subcellular Location:
        Cell membrane; Single-pass type I membrane protein. Melanosome.

        Tissue Specificity:
        Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

        Post-translational modifications:
        N-glycosylated.

        Similarity:
        Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
        Contains 1 Ig-like V-type (immunoglobulin-like) domain.

        Database links:

        Entrez Gene: 682 Human

        Entrez Gene: 12215 Mouse

        Entrez Gene: 25246 Rat

        Omim: 109480 Human

        SwissProt: P35613 Human

        SwissProt: P18572 Mouse

        SwissProt: P26453 Rat

        Unigene: 501293 Human



        Important Note:
        This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

        合成與降解(Synthesis and Degradation)
        主要由腫瘤細胞合成,刺激纖維母細胞產生MMP
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