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        Azurocidin/HBP Mouse mAb (V4601)  
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        定制/大包裝/詢價
        大包裝/詢價
        產品編號 V4601
        英文名稱 Azurocidin/HBP Mouse mAb
        中文名稱 天青素/肝素結合蛋白單克隆抗體
        別    名 Azu 1; Azu1; CAP37; CAP7_HUMAN; cationic antimicrobial protein 37; Cationic antimicrobial protein CAP37; HBP; Heparin binding protein; Heparin-binding protein; HUMAZUR.  肝素結合蛋白; 陽離子抗菌蛋白37; 天青殺素;
        克 隆 號 4A2
        理論分子量 24 kDa
        檢測分子量
        細胞定位 細胞漿 
        性    狀 Liquid
        緩 沖 液 0.01M PBS (pH7.4).
        保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
        注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
        產品介紹 This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.

        Function:
        This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

        Subunit:
        Monomer.

        Subcellular Location:
        Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils.
        Belongs to the peptidase S1 family. Elastase subfamily.
        Contains 1 peptidase S1 domain.

        Similarity:
        Belongs to the peptidase S1 family. Elastase subfamily.
        Contains 1 peptidase S1 domain.

        SWISS:
        P20160

        Gene ID:
        566

        Database links:

        Entrez Gene: 566 Human

        Omim: 162815 Human

        SwissProt: P20160 Human

        Unigene: 72885 Human



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