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        Placental lactogen I+II Rabbit pAb (bs-12940R)  
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        產品編號 bs-12940R
        英文名稱 Placental lactogen I+II Rabbit pAb
        中文名稱 胎盤催乳素1/2抗體
        別    名 Choriomammotropin; Chorionic somatomammotropin B; Chorionic somatomammotropin hormone 2; Chorionic somatomammotropin hormone; CS 2; CS2; CSB; CSH_HUMAN; CSH1; CSH2; hCS B; HCSB; Lactogen; mPL II; mplII; Pl 2; PL; Pl2; Placental lactogen; Placental lactogen II; Prl3b1; Prolactin 3B1; prolactin family 3, subfamily b, member 1; Placental lactogen I; Placental lactogen II; rPLII.  
        研究領域 細胞生物  免疫學  發育生物學  信號轉導  生長因子和激素  內分泌病  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        克 隆 號
        交叉反應 Human,Mouse
        產品應用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        理論分子量 22 kDa
        檢測分子量
        細胞定位 分泌型蛋白 
        性    狀 Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthetic peptide derived from human CSH2/Placental lactogen I/II: 110-217/217 
        亞    型 IgG
        純化方法 affinity purified by Protein A
        緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
        保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
        注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
        PubMed PubMed
        產品介紹 Placental lactogens, also referred to as chorionic somatomammotropin hormones, are protein hormones. They are produced in the mammalian placenta and are similar in structure and function to growth hormones. Together, placental lactogens and growth factors play an essential role to assure successful lactation after pregnancy. Placental lactogens also modify the metabolic state of the mother during pregnancy to supply energy to the fetus. Placental lactogen I is a member of the somatotropin/prolactin family of hormones. The proteins in this family are crucial in mammalian growth control. Placental lactogen I is expressed primarily during mid-pregnancy, and it has been reported that DNA methylation regulates its tissue expression in rats. Placental lactogen II is expressed later in pregnancy and, in mice, its secretion is regulated by the inhibitory control of GH, the concentration of which increases rapidly at the beginning of the last half of pregnancy.

        Function:
        Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.

        Subcellular Location:
        Secreted.

        Similarity:
        Belongs to the somatotropin/prolactin family.

        SWISS:
        P0DML3

        Gene ID:
        1443

        Database links:

        Entrez Gene: 1442 Human

        Entrez Gene: 1443 Human

        Omim: 150200 Human

        SwissProt: P0DML3  Human

        Unigene: 654390 Human




        產品圖片
        Tissue/cell: mouse placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Placental lactogen I+II Polyclonal Antibody, Unconjugated(bs-12940R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
        Tissue/cell: mouse embryo tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Placental lactogen I+II Polyclonal Antibody, Unconjugated(bs-12940R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
        Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Placental lactogen I+II Polyclonal Antibody, Unconjugated(bs-12940R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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