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        Thrombospondin 2 Rabbit pAb (bs-7524R)  
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        產品編號 bs-7524R
        英文名稱 Thrombospondin 2 Rabbit pAb
        中文名稱 血小板反應蛋白2/凝血酶敏感蛋白2抗體
        別    名 THBS2; Thrombospondin-2; Thrombospondin2; TSP2; TSP2_HUMAN.  
        Specific References  (3)     |     bs-7524R has been referenced in 3 publications.
        [IF=4.638] Li Jianxiong. et al. Whole-exome mutational landscape and molecular marker study in mucinous and clear cell ovarian cancer cell lines 3AO and ES2. BMC CANCER. 2023 Dec;23(1):1-13  WB,IF ;  Human.  
        [IF=2.22] Ken-Go Hayashi. et al. Differential expression of pro- and anti-angiogenic factors in the endometrium between repeat breeder and normally fertile cows. ANIM REPROD SCI. 2023 Jul;254:107265  IHC ;  Bovine.  
        [IF=1.33] Chen, Junying, et al. "MiR-1246 promotes SiHa cervical cancer cell proliferation, invasion, and migration through suppression of its target gene thrombospondin 2." Archives of Gynecology and Obstetrics (2014): 1-8.  WB ;  Human.  
        研究領域 腫瘤  心血管  細胞生物  細胞因子  
        抗體來源 Rabbit
        克隆類型 Polyclonal
        克 隆 號
        交叉反應 Human (predicted: Mouse,Rat,Horse)
        產品應用 WB=1:500-2000
        not yet tested in other applications.
        optimal dilutions/concentrations should be determined by the end user.
        理論分子量 128 kDa
        檢測分子量
        細胞定位 細胞外基質 分泌型蛋白 
        性    狀 Liquid
        濃    度 1mg/ml
        免 疫 原 KLH conjugated synthetic peptide derived from human Thrombospondin 2: 201-300/1172 
        亞    型 IgG
        純化方法 affinity purified by Protein A
        緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
        保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
        注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
        PubMed PubMed
        產品介紹 Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

        Function:
        Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

        Subunit:
        Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

        Tissue Specificity:
        High expression in invertebral disk tissue.

        DISEASE:
        Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD) [MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and the predominant cause of low-back pain and unilateral leg pain.

        Similarity:
        Belongs to the thrombospondin family.
        Contains 2 EGF-like domains.
        Contains 1 laminin G-like domain.
        Contains 1 TSP C-terminal (TSPC) domain.
        Contains 3 TSP type-1 domains.
        Contains 8 TSP type-3 repeats.
        Contains 1 VWFC domain.

        SWISS:
        P35442

        Gene ID:
        7058

        Database links:

        Entrez Gene: 7058 Human

        Entrez Gene: 21826 Mouse

        Entrez Gene: 292406 Rat

        Omim: 188061 Human

        SwissProt: P35440 Chicken

        SwissProt: Q95116 Cow

        SwissProt: P35442 Human

        SwissProt: Q03350 Mouse

        Unigene: 797 Chicken

        Unigene: 5522 Cow

        Unigene: 371147 Human

        Unigene: 26688 Mouse



        產品圖片
        Sample: MG63(Human) Cell Lysate at 40 ug Primary: Anti-Thrombospondin 2 (bs-7524R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 128 kD Observed band size: 128 kD
        Sample: HUVEC(Human) Cell Lysate at 40 ug Primary: Anti-Thrombospondin 2 (bs-7524R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 128 kD Observed band size: 128 kD
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